rs10936600
This is a protein-altering variant in the LRRC34 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
chromosome, telomeric region length
Li C et al. “Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.” American Journal of Human Genetics 106(3):389-404 (2020)
Allele T
OR 0.09
p 7.0e-51
N 78,592
Large GWAS
European
nevus count, cutaneous melanoma
Landi MT et al. “Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility.” Nature Genetics 52(5):494-504 (2020)
Allele A
OR —
p 5.0e-16
N 477,725
Large GWAS
European
multiple myeloma
Mitchell JS et al. “Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.” Nature Communications 7:12050 (2016)
Allele A
OR 1.20
p 6.0e-15
N 241,704
Large GWAS
European
female genital tract polyp
Pathare ADS et al. “A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth.” Human Reproduction (oxford, England) 40(4):750-763 (2025)
Allele A
OR 1.05
p 9.0e-9
N 457,977
Large GWAS
European
basal cell carcinoma
Choquet H et al. “Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma.” Communications Biology 7(1):33 (2024)
Allele T
OR 0.96
p 5.0e-8
N 812,765
Meta-analysisLarge GWAS
multi-ancestry
About LRRC34
Predicted to be involved in cell differentiation. Predicted to act upstream of or within gene expression and telomere maintenance. Predicted to be located in cytoplasm and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
View all LRRC34 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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