rs11024102
This variant is located in the PLEKHA7 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
retinal layer thickness
Jackson VE et al. “Multi-omic spatial effects on high-resolution AI-derived retinal thickness.” Nature Communications 16(1):1317 (2025)
Allele C
OR 18.63
p 1.0e-14
N 43,151
Large GWAS
multi-ancestry
glaucoma
Vithana EN et al. “Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.” Nature Genetics 44(10):1142-1146 (2012)
Allele G
OR 1.22
p 5.0e-12
N 11,462
Large GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.09
p 1.0e-8
N 177,351
Large GWAS
East Asian
open-angle glaucoma
Zhou W et al. “Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.” Cell Genomics 2(10):100192 (2022)
Allele C
OR 0.06
p 2.0e-10
N 1,487,447
Meta-analysisLarge GWAS
multi-ancestry
intraocular pressure measurement
Gao XR et al. “Genome-wide association analyses identify new loci influencing intraocular pressure.” Human Molecular Genetics 27(12):2205-2213 (2018)
Allele T
OR 0.10
p 3.0e-10
N 115,486
Large GWAS
European
primary angle closure glaucoma
Khor CC et al. “Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma.” Nature Genetics 48(5):556-62 (2016)
Allele G
OR 1.18
p 2.0e-18
N 26,454
Large GWAS
multi-ancestry
About PLEKHA7
Enables delta-catenin binding activity. Involved in epithelial cell-cell adhesion; pore complex assembly; and zonula adherens maintenance. Located in several cellular components, including centrosome; nucleoplasm; and zonula adherens. Part of pore complex. [provided by Alliance of Genome Resources, Jul 2025]
View all PLEKHA7 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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