rs11066015

This is a intron variant variant in the ACAD10 gene.

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GWAS Catalog Trait Associations (28)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

mean corpuscular hemoglobin

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.10
p 4.0e-129
N 478,500
Large GWAS
multi-ancestry

high density lipoprotein cholesterol measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.12
p 2.0e-109
N 390,103
Large GWAS
multi-ancestry

erythrocyte volume

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.09
p 3.0e-91
N 480,305
Large GWAS
multi-ancestry

serum creatinine amount

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.04
p 1.0e-85
N 928,679
Large GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.04
p 2.0e-31
N 150,266
Large GWAS
East Asian

low density lipoprotein cholesterol measurement

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.04
p 9.0e-45
N 928,679
Large GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.07
p 5.0e-33
N 416,487
Large GWAS
multi-ancestry

erythrocyte count

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.05
p 7.0e-41
N 153,512
Large GWAS
East Asian

blood urea nitrogen amount

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.05
p 4.0e-31
N 492,819
Large GWAS
multi-ancestry
Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)
Allele A
OR 0.02
p 5.0e-19
N 58,406
Large GWAS
East Asian

body height

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.02
p 9.0e-29
N 928,679
Large GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.02
p 1.0e-14
N 525,444
Large GWAS
multi-ancestry

aspirin use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.10
p 1.0e-23
N 178,726
Large GWAS
East Asian

polyp of colon

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.24
p 1.0e-21
N 525,237
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: A population‐based case–control study in China
AssociationN=1,925Ming Wu et al.(2013)· International Journal of Cancer

Population-based case-control study in China examining alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms in esophageal cancer. ADH1B rs1229984 G-allele showed significant association with esophageal cancer risk (OR=1.34, dominant model), and ALDH2 rs671 showed significant gene-environment interaction with alcohol consumption, with moderate/heavy drinkers carrying ALDH2 A allele and ADH G allele at highest risk. No association found for ADH1C rs698 polymorphism.

Traits studied:Esophageal cancerEsophageal squamous cell carcinoma
PubMedDOIMetascience Observatory

About ACAD10

This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]

View all ACAD10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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