rs11066280

This is a intron variant variant in the HECTD4 gene.

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GWAS Catalog Trait Associations (13)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

drinking behavior

Yang X et al. “Common variants at 12q24 are associated with drinking behavior in Han Chinese.” The American Journal of Clinical Nutrition 97(3):545-51 (2013)
Allele T
OR 3.33
p 3.0e-215
N 5,010
Large GWAS
East Asian

diastolic blood pressure

Kato N et al. “Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.” Nature Genetics 43(6):531-8 (2011)
Allele T
OR 1.01
p 1.0e-35
N 19,608
Meta-analysisLarge GWAS
East Asian
Kato N et al. “Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.” Nature Genetics 47(11):1282-1293 (2015)
Allele T
OR 0.89
p 2.0e-11
N 99,994
Large GWAS
multi-ancestry
Lu X et al. “Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.” Human Molecular Genetics 24(3):865-74 (2015)
Allele T
OR 0.62
p 3.0e-10
N 11,816
Large GWAS
East Asian

systolic blood pressure

Kato N et al. “Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.” Nature Genetics 43(6):531-8 (2011)
Allele T
OR 1.56
p 8.0e-31
N 19,608
Meta-analysisLarge GWAS
East Asian
Kato N et al. “Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.” Nature Genetics 47(11):1282-1293 (2015)
Allele T
OR 1.24
p 7.0e-9
N 99,994
Large GWAS
multi-ancestry

body weight

Cho HW et al. “A Genome-Wide Association Study of Novel Genetic Variants Associated With Anthropometric Traits in Koreans.” Frontiers in Genetics 12:669215 (2021)
Allele T
OR 0.01
p 8.0e-20
N 5,472
Large GWAS
East Asian

myocardial infarction

Yamada Y et al. “Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease.” International Journal of Molecular Medicine 42(5):2415-2436 (2018)
Allele A
OR 1.49
p 7.0e-17
N 6,926
Large GWAS
East Asian

coronary artery disease

Lu X et al. “Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.” Nature Genetics 44(8):890-4 (2012)
Allele A
OR 1.19
p 2.0e-11
N 6,534
Large GWAS
East Asian

uric acid measurement

Yasukochi Y et al. “Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.” Molecular Genetics and Genomics : Mgg 293(2):371-379 (2018)
Allele A
OR 8.78
p 6.0e-11
N 5,847
Large GWAS
East Asian
Cho SK et al. “Polygenic analysis of the effect of common and low-frequency genetic variants on serum uric acid levels in Korean individuals.” Scientific Reports 10(1):9179 (2020)
Allele A
OR 0.14
p 3.0e-9
N 6,881
Large GWAS
East Asian

triglyceride measurement

Lu X et al. “Genetic Susceptibility to Lipid Levels and Lipid Change Over Time and Risk of Incident Hyperlipidemia in Chinese Populations.” Circulation. Cardiovascular Genetics 9(1):37-44 (2016)
Allele T
OR 0.02
p 1.0e-8
N 8,344
Large GWAS
East Asian

About HECTD4

Predicted to enable ubiquitin-protein transferase activity. Involved in glucose homeostasis and glucose metabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all HECTD4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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