rs115292790

This is a upstream gene variant variant in the STXBP3 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

low density lipoprotein cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele A

OR 0.06

p 1.0e-15

N 1,320,016

Large GWAS

European

total cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele A

OR 0.04

p 3.0e-9

N 1,320,016

Large GWAS

European

About STXBP3

Enables syntaxin binding activity. Involved in negative regulation of calcium ion-dependent exocytosis; neutrophil degranulation; and platelet aggregation. Located in cytosol; plasma membrane; and secretory granule. [provided by Alliance of Genome Resources, Jul 2025]

View all STXBP3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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