rs11558819
This variant is located in the ICOSLG gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
blood protein amount
Emilsson V et al. “Co-regulatory networks of human serum proteins link genetics to disease.” Science (new York, N.y.) 361(6404):769-773 (2018)
Allele C
OR 0.79
p 6.0e-194
N 3,200
Large GWAS
European
Kuliesius J et al. “Efficient candidate drug target discovery through proteogenomics in a Scottish cohort.” Communications Biology 8(1):1300 (2025)
Allele C
OR 0.65
p 4.0e-13
N 198
Small GWAS
European
icos ligand measurement
Allele T
OR —
β 0.580
p 4.0e-108
N 3,301
Large GWAS
European
rheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement
Saevarsdottir S et al. “Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.” Annals of the Rheumatic Diseases 81(8):1085-1095 (2022)
Allele T
OR 0.91
p 2.0e-9
N 1,009,623
Large GWAS
European
▶ClinVar annotation
About ICOSLG
Enables identical protein binding activity and receptor ligand activity. Involved in T follicular helper cell differentiation. Located in intracellular membrane-bounded organelle. Is active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
View all ICOSLG variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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