rs11621145

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

IgG index

Goris A et al. “Genetic variants are major determinants of CSF antibody levels in multiple sclerosis.” Brain : a Journal of Neurology 138(Pt 3):632-43 (2015)
Allele G
OR 0.23
p 4.0e-37
N 938
Small GWAS
multi-ancestry

cholesterol to total lipids in small LDL percentage

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.03
p 1.0e-35
N 450,015
Large GWAS
multi-ancestry

complement C1s subcomponent measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.19
p 1.0e-30
N 10,708
Large GWAS
European

free cholesterol to total lipids in very small VLDL percentage

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 6.0e-17
N 450,015
Large GWAS
multi-ancestry

complement C1r subcomponent measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.14
p 7.0e-17
N 10,708
Large GWAS
European

total lipids in large LDL

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 5.0e-16
N 450,015
Large GWAS
multi-ancestry

serum albumin amount

Harrison S et al. “Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank.” Science Advances 7(31) (2021)
Allele A
OR 0.08
p 1.0e-9
N 158,000
Major Consortium StudyLarge GWAS
European
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Research that mentions this SNP (1)

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Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis
AssociationN=638Dorothea Buck et al.(2013)· Annals of Neurology

A genome-wide association study identified five SNPs in the immunoglobulin heavy chain locus (IGHC) on chromosome 14q32.33 associated with the IgG index, a measure of intrathecal IgG synthesis in multiple sclerosis patients. The strongest association was rs10136766 (p = 7.5 × 10⁻¹⁶), which explained 8.9% of variance and was associated with the GM21* haplotype. These SNPs showed no association with MS susceptibility itself.

Traits studied:IgG indexIntrathecal IgG synthesisMultiple sclerosis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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