rs11639856

This variant is located in the TNRC6A gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele T
OR 0.01
p 3.0e-18
N 1,122,049
Large GWAS
European

whole body water mass

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.01
p 2.0e-13
N 394,642
Large GWAS
European

grip strength measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.01
p 4.0e-12
N 394,642
Large GWAS
European

systolic blood pressure

Liu C et al. “Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.” Nature Genetics 48(10):1162-70 (2016)
Allele A
OR 0.34
p 1.0e-8
N 146,562
Meta-analysisLarge GWAS
multi-ancestry

pulse pressure measurement

Liu C et al. “Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.” Nature Genetics 48(10):1162-70 (2016)
Allele A
OR 0.23
p 2.0e-8
N 146,562
Meta-analysisLarge GWAS
multi-ancestry
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ClinVar annotation

Benign★★★☆
3 submitters1 publication

not provided; Epilepsy, familial adult myoclonic, 6

View on ClinVar →

About TNRC6A

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

View all TNRC6A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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