TNRC6A

trinucleotide repeat containing adaptor 6A

Summary

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

Known Variants132 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs8045064	16:24,675,589	T/C	intron variant	—
rs8051058	16:24,699,511	T/C	intergenic variant	—
rs7184364	16:24,714,271	A/G	intergenic variant	—
rs12708664	16:24,718,310	G/C	—	—
rs9921750	16:24,724,778	T/A	—	—
rs200541	16:24,733,141	A/T	—	—
rs13329943	16:24,733,751	C/T	—	—
rs200539	16:24,735,178	T/C	regulatory region variant	—
rs200534	16:24,752,641	G/C	—	—
rs181042823	16:24,761,046	G/A	intron variant	—
rs375656692	16:24,769,676	T/C	—	uncertain significance
rs751765781	16:24,788,265	A/T	—	uncertain significance
rs781374556	16:24,788,275	G/C	—	uncertain significance
rs1357180882	16:24,788,309	C/G	—	uncertain significance
rs573912317	16:24,788,375	A/G	—	likely benign
rs1218950214	16:24,788,410	A/C	—	uncertain significance
rs201072103	16:24,788,481	C/T	—	uncertain significance
rs370106844	16:24,788,496	G/A	—	uncertain significance
rs117821015	16:24,788,549	G/A	—	benign
rs11639856	16:24,788,645	T/A	—	benign
rs771019356	16:24,788,665	G/A	—	uncertain significance
rs761157858	16:24,800,598	G/A	—	uncertain significance
rs750316536	16:24,800,624	T/A	—	uncertain significance
rs202159827	16:24,800,633	A/G	—	uncertain significance
rs770908114	16:24,800,670	A/G	—	uncertain significance
rs764631562	16:24,800,688	C/T	—	likely benign
rs373034622	16:24,800,786	A/G	—	uncertain significance
rs148540830	16:24,800,871	A/C	—	uncertain significance
rs147262497	16:24,800,919	C/A	—	uncertain significance
rs778056188	16:24,800,973	G/A	—	uncertain significance
rs753233814	16:24,801,063	A/G	—	uncertain significance
rs200481091	16:24,801,078	T/C	—	uncertain significance
rs2545657905	16:24,801,127	T/G	—	uncertain significance
rs2058058860	16:24,801,145	G/A	—	uncertain significance
rs2545660070	16:24,801,255	T/A	—	uncertain significance
rs370982742	16:24,801,300	T/C	—	uncertain significance
rs2058063483	16:24,801,343	G/C	—	uncertain significance
rs1324993351	16:24,801,393	G/A	—	uncertain significance
rs375501182	16:24,801,414	G/A	—	uncertain significance
rs1272908153	16:24,801,423	C/T	—	uncertain significance
rs199855746	16:24,801,425	A/G	—	uncertain significance
rs748168449	16:24,801,531	G/T	—	uncertain significance
rs752407150	16:24,801,575	A/G	—	uncertain significance
rs758203450	16:24,801,621	C/T	—	uncertain significance
rs144051257	16:24,801,635	C/T	—	uncertain significance
rs146442938	16:24,801,638	A/G	—	benign
rs555251368	16:24,801,671	G/A	—	uncertain significance
rs573474554	16:24,801,696	C/T	—	conflicting classifications of pathogenicity
rs2058073143	16:24,801,722	G/A	—	uncertain significance
rs372228558	16:24,801,726	G/A	—	conflicting classifications of pathogenicity
rs6497759	16:24,801,737	G/A	—	benign
rs768309586	16:24,801,756	G/A	—	uncertain significance
rs757299851	16:24,801,792	C/G	—	uncertain significance
rs150474828	16:24,801,795	A/G	—	uncertain significance
rs2058076666	16:24,801,866	A/G	—	uncertain significance
rs371231691	16:24,801,878	A/G	—	uncertain significance
rs138156310	16:24,801,914	T/C	—	uncertain significance
rs755356378	16:24,801,920	A/G	—	uncertain significance
rs2545670997	16:24,801,972	T/A	—	uncertain significance
rs13336754	16:24,801,979	T/C	—	benign
rs1159877006	16:24,802,143	C/G	—	uncertain significance
rs113288384	16:24,802,204	C/T	—	likely benign
rs118000672	16:24,802,206	A/G	—	uncertain significance
rs201394419	16:24,802,316	G/A	—	uncertain significance
rs3803716	16:24,802,325	C/T	—	benign
rs139212478	16:24,802,366	G/A	—	benign
rs542620759	16:24,802,368	G/T	—	uncertain significance
rs764926104	16:24,802,398	G/T	—	uncertain significance
rs143822830	16:24,802,427	T/C	—	conflicting classifications of pathogenicity
rs148154296	16:24,802,445	G/A	—	uncertain significance
rs150912811	16:24,802,572	A/G	—	likely benign
rs764032897	16:24,802,667	A/G	—	uncertain significance
rs370621058	16:24,802,712	A/G	—	uncertain significance
rs2545683184	16:24,802,729	G/C	—	uncertain significance
rs377540104	16:24,802,826	T/C	—	uncertain significance
rs2545685112	16:24,802,869	G/C	—	uncertain significance
rs756268104	16:24,802,950	G/A	—	uncertain significance
rs368712374	16:24,802,953	G/A	—	uncertain significance
rs139403173	16:24,802,972	C/T	—	benign
rs201134729	16:24,803,045	A/G	—	uncertain significance
rs1166138434	16:24,803,053	C/G	—	uncertain significance
rs749539505	16:24,803,058	G/A	—	uncertain significance
rs766162498	16:24,803,094	C/T	—	uncertain significance
rs2545688884	16:24,803,109	T/C	—	uncertain significance
rs865841980	16:24,803,116	C/G	—	uncertain significance
rs1862451	16:24,803,620	A/T	—	—
rs759186892	16:24,804,800	G/A	—	uncertain significance
rs778710185	16:24,804,895	G/A	—	uncertain significance
rs753005808	16:24,804,939	C/A	—	uncertain significance
rs113388806	16:24,804,954	A/G	synonymous variant	—
rs1167823140	16:24,805,876	A/G	—	uncertain significance
rs994893045	16:24,805,957	A/T	—	uncertain significance
rs7186893	16:24,806,420	G/C	—	—
rs748294806	16:24,808,842	A/C	—	uncertain significance
rs1263573480	16:24,808,845	C/T	—	uncertain significance
rs17177078	16:24,810,681	C/T	downstream gene variant	—
rs964782	16:24,811,740	T/C	downstream gene variant	—
rs369985370	16:24,815,511	C/G	—	uncertain significance
rs147882985	16:24,815,551	G/A	—	uncertain significance
rs2058385037	16:24,815,594	A/C	—	uncertain significance

Showing 100 of 132 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.