rs11697662

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cigarettes per day measurement

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.03
p 6.0e-53
N 618,489
Large GWAS
European
Xu K et al. “Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.” Nature Communications 11(1):5302 (2020)
Allele T
OR —
β 0.016
p 7.0e-9
N 17,014
Meta-analysisLarge GWAS
European

smoking behavior trait

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.07
p 3.0e-16
N 231,654
Major Consortium StudyLarge GWAS
European

leukocyte quantity

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele T
OR 0.02
p 3.0e-14
N 928,679
Large GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.03
p 3.0e-14
N 381,267
Major Consortium StudyLarge GWAS
European

neutrophil count

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 2.0e-12
N 275,068
Major Consortium StudyLarge GWAS
European

drug use measurement, chronic lung disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.07
p 2.0e-11
N 400,487
Major Consortium StudyLarge GWAS
multi-ancestry

squamous cell lung carcinoma

Gorman BR et al. “Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.” Nature Communications 15(1):8629 (2024)
Allele T
OR 0.90
p 2.0e-9
N 135,790
Large GWAS
multi-ancestry

lung cancer, family history of lung cancer

Gabriel AAG et al. “Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.” Journal of the National Cancer Institute 114(8):1159-1166 (2022)
Allele C
OR 1.07
p 1.0e-8
N 329,946
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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