rs11755724

This variant is located in the RREB1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

gout

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.09
p 1.0e-25
N 404,034
Major Consortium StudyLarge GWAS
multi-ancestry
Sandoval-Plata G et al. “Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank.” Annals of the Rheumatic Diseases 80(9):1220-1226 (2021)
Allele A
OR 1.17
p 9.0e-15
N 71,473
Major Consortium StudyLarge GWAS
European

glomerular filtration rate

Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)
Allele A
OR 0.00
p 1.0e-19
N 765,348
Large GWAS
multi-ancestry

drug use measurement, gout

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.09
p 1.0e-18
N 315,668
Major Consortium StudyLarge GWAS
European

About RREB1

The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

View all RREB1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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