RREB1

ras responsive element binding protein 1

Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Known Variants319 total

rsidPosition (GRCh37)AllelesClassClinVar
rs28428956:7,106,316G/A——
rs1887621616:7,108,984G/Cregulatory region variant—
rs39046006:7,109,665C/A——
rs117557246:7,118,990A/T——
rs132082346:7,119,134G/Aintron variant—
rs6874676:7,128,076A/T——
rs131938876:7,128,198G/Tintron variant—
rs5511436:7,136,772A/Gintron variant—
rs49594266:7,160,014G/Aregulatory region variant—
rs5129766:7,163,873C/Tintron variant—
rs1491247196:7,182,150G/A—benign
rs1168214476:7,182,155G/A—likely benign
rs7454413796:7,182,158C/G—uncertain significance
rs3679224836:7,182,163G/A—uncertain significance
rs7634732766:7,182,175G/A—uncertain significance
rs10064692316:7,182,209C/T—uncertain significance
rs1168215386:7,182,213G/A—likely benign
rs1166042366:7,182,231G/A—likely benign
rs1399822756:7,182,273C/T—likely benign
rs2009557556:7,182,276G/A—likely benign
rs1410078366:7,182,280C/T—conflicting classifications of pathogenicity
rs733746626:7,189,398A/G—benign
rs1401140546:7,189,401G/A—uncertain significance
rs7613056036:7,189,404A/G—uncertain significance
rs8934150566:7,189,418C/A—uncertain significance
rs562330316:7,189,454G/A—likely benign
rs14326193636:7,189,500C/T—uncertain significance
rs5685813146:7,189,512A/G—uncertain significance
rs13673713566:7,189,544G/A—likely benign
rs15815133756:7,189,564G/A—likely benign
rs49594296:7,194,182A/Gintron variant—
rs776300706:7,196,323G/A——
rs5508249406:7,202,650C/T——
rs69215806:7,203,714C/T——
rs762075906:7,203,995A/G——
rs25330316756:7,211,078C/A—uncertain significance
rs1425101796:7,211,091A/G—likely benign
rs12263741206:7,211,092T/C—uncertain significance
rs1144406126:7,211,096C/T—uncertain significance
rs15815426646:7,211,113T/C—likely benign
rs17665459586:7,211,123A/G—uncertain significance
rs1153181216:7,211,164C/A—likely benign
rs7666023186:7,211,879A/G—uncertain significance
rs7536436506:7,211,928A/G—likely benign
rs176039456:7,213,016G/Aintron variant—
rs69190046:7,215,541C/Tregulatory region variant—
rs21519416:7,216,167A/Gregulatory region variant—
rs69312626:7,217,517C/Tregulatory region variant—
rs93790826:7,220,960T/Cregulatory region variant—
rs93790836:7,221,443G/T——
rs5476896706:7,226,754C/T—likely benign
rs1381814016:7,226,755G/A—likely benign
rs7591014446:7,226,757G/A—likely benign
rs3761955186:7,226,823T/C—likely benign
rs1150034476:7,226,838C/T—benign
rs7723441986:7,226,852C/T—uncertain significance
rs1432924396:7,226,878C/T—uncertain significance
rs95050856:7,226,959C/Tintron variant—
rs27143116:7,228,046T/A——
rs7741805396:7,229,224A/G—likely benign
rs7562055506:7,229,303C/T—uncertain significance
rs7743401956:7,229,311A/G—uncertain significance
rs1460249956:7,229,328T/C—likely benign
rs27143156:7,229,346T/C—benign
rs1499138456:7,229,352G/A—likely benign
rs17677569686:7,229,353G/A—uncertain significance
rs1131140646:7,229,356G/A—benign
rs7562973666:7,229,360A/G—uncertain significance
rs7493600716:7,229,370A/G—likely benign
rs10294210036:7,229,387C/T—uncertain significance
rs7797865356:7,229,389C/T—likely benign
rs1397992236:7,229,400C/T—likely benign
rs7529905846:7,229,419T/C—uncertain significance
rs3764038966:7,229,469C/T—likely benign
rs14418386646:7,229,543C/A—uncertain significance
rs1421502706:7,229,544C/T—benign
rs1467444946:7,229,545G/A—conflicting classifications of pathogenicity
rs1153741136:7,229,549G/A—conflicting classifications of pathogenicity
rs7725256266:7,229,575T/C—uncertain significance
rs1509940446:7,229,593G/A—uncertain significance
rs1409803546:7,229,595C/T—likely benign
rs10399415996:7,229,616C/T—likely benign
rs3686067256:7,229,617G/C—uncertain significance
rs121926726:7,229,619A/G—likely benign
rs7692629446:7,229,642T/C—uncertain significance
rs1995656906:7,229,707A/G—likely benign
rs7567374136:7,229,721G/A—likely benign
rs17677875366:7,229,791C/T—uncertain significance
rs7532092056:7,229,793G/A—likely benign
rs14688262606:7,229,867T/A—uncertain significance
rs3773009956:7,229,875C/T—uncertain significance
rs13799766336:7,229,886G/A—likely benign
rs7802190106:7,229,900C/T—uncertain significance
rs1415345056:7,229,919C/T—likely benign
rs1505277886:7,229,936C/A—uncertain significance
rs1166720336:7,229,974A/C—benign
rs10451570986:7,229,984A/G—uncertain significance
rs764308686:7,229,991A/G—benign
rs7657250566:7,229,999C/T—uncertain significance
rs7814710576:7,230,010G/A—uncertain significance

Showing 100 of 319 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.