rs11852372

This is a intron variant variant in the HYKK gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cigarettes per day measurement

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele C
OR 0.10
p 4.9e-324
N 783,784
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified
Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)
Allele C
OR 0.08
p 1.0e-183
N 337,334
Large GWAS
European

C-reactive protein measurement

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)
Allele A
OR 0.01
p 5.0e-11
N 575,531
Large GWAS
European

emphysema pattern measurement

Castaldi PJ et al. “Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.” American Journal of Respiratory and Critical Care Medicine 190(4):399-409 (2014)
Allele A
OR 0.00
p 2.0e-10
N 9,614
Large GWAS
multi-ancestry

heart failure

Lee DSM et al. “Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.” Nature Genetics 57(4):829-838 (2025)
Allele A
OR 0.03
p 2.0e-10
N 2,358,556
Large GWAS
multi-ancestry

About HYKK

Enables hydroxylysine kinase activity. Predicted to be involved in lysine catabolic process. Predicted to be located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

View all HYKK variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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