rs11897119

This variant is located in the MEIS1 gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

waist-hip ratio

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele T
OR 0.01
p 4.0e-15
N 697,734
Meta-analysisLarge GWAS
European

systolic blood pressure

Surendran P et al. “Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.” Nature Genetics 52(12):1314-1332 (2020)
Allele T
OR 0.16
p 6.0e-13
N 1,164,961
Meta-analysisLarge GWAS
European

PR interval

Pfeufer A et al. “Genome-wide association study of PR interval.” Nature Genetics 42(2):153-9 (2010)
Allele C
OR 1.36
p 5.0e-11
N 28,517
Large GWAS
European

pulse pressure measurement

Surendran P et al. “Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.” Nature Genetics 52(12):1314-1332 (2020)
Allele T
OR 0.10
p 5.0e-9
N 1,164,961
Meta-analysisLarge GWAS
European

BMI-adjusted waist-hip ratio, physical activity measurement

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele C
OR 0.02
p 2.0e-8
N 156,653
Meta-analysisLarge GWAS
multi-ancestry

About MEIS1

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]

View all MEIS1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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