rs12229654
This is a intergenic variant variant.
▶GWAS Catalog Trait Associations (12)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (12)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
serum gamma-glutamyl transferase measurement
Kim YJ et al. “Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.” Nature Genetics 43(10):990-5 (2011)
Allele G
OR 0.01
p 9.0e-58
N 12,545
Large GWAS
East Asian
alcohol consumption quality, alcohol drinking
Jorgenson E et al. “Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.” Molecular Psychiatry 22(9):1359-1367 (2017)
Allele G
OR 2.31
p 2.0e-48
N 86,627
Large GWAS
multi-ancestry
alcohol drinking
Baik I et al. “Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.” The American Journal of Clinical Nutrition 93(4):809-16 (2011)
Allele G
OR 0.79
p 4.0e-35
N 1,721
Large GWAS
East Asian
atrial fibrillation
Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)
Allele T
OR 0.25
p 2.0e-32
N 2,584,013
Large GWAS
multi-ancestry
hypertension
Jeong H et al. “Identifying Interactions between Dietary Sodium, Potassium, Sodium-Potassium Ratios, and FGF5 rs16998073 Variants and Their Associated Risk for Hypertension in Korean Adults.” Nutrients 12(7) (2020)
Allele G
OR 0.79
p 4.0e-25
N 17,736
Large GWAS
East Asian
high density lipoprotein cholesterol measurement
Kim YJ et al. “Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.” Nature Genetics 43(10):990-5 (2011)
Allele G
OR 0.03
p 3.0e-23
N 12,545
Large GWAS
East Asian
type 2 diabetes mellitus
Go MJ et al. “New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.” Journal of Human Genetics 58(6):362-5 (2013)
Allele G
OR 0.28
p 9.0e-13
N 7,696
Large GWAS
East Asian
myocardial infarction
Yamada Y et al. “Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease.” International Journal of Molecular Medicine 42(5):2415-2436 (2018)
Allele G
OR 1.39
p 1.0e-10
N 6,926
Large GWAS
East Asian
carbohydrate intake measurement
Nakamura Y et al. “A genome-wide association study on adherence to low-carbohydrate diets in Japanese.” European Journal of Clinical Nutrition 76(8):1103-1110 (2022)
Allele G
OR 1.10
p 3.0e-10
N 6,332
Large GWAS
East Asian
body mass index
Wen W et al. “Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.” Human Molecular Genetics 23(20):5492-504 (2014)
Allele T
OR 0.03
p 5.0e-9
N 86,739
Meta-analysisLarge GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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