rs12582330

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hypothyroidism

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele T

OR 0.05

p 3.0e-30

N 1,786,062

Large GWAS

European

Rand SA et al. “Genome-wide association study and polygenic risk prediction of hypothyroidism.” Nature Genetics 57(12):3007-3015 (2025)

Allele T

OR 0.05

p 1.0e-21

N 1,178,661

Large GWAS

European

Figuerêdo J et al. “Uncovering the shared genetic components of thyroid disorders and reproductive health.” European Journal of Endocrinology 191(2):211-222 (2024)

Allele T

OR 1.07

p 1.0e-15

N 691,986

Large GWAS

European

Mathieu S et al. “Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms.” Iscience 25(9):104992 (2022)

Allele T

OR 0.07

p 1.0e-16

N 494,577

Large GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.08

p 9.0e-16

N 394,626

Large GWAS

European

autoimmune thyroid disease

Saevarsdottir S et al. “FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.” Nature 584(7822):619-623 (2020)

Allele G

OR 1.08

p 8.0e-15

N 754,406

Large GWAS

European

Zeng Y et al. “Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.” The American Journal of Psychiatry 180(4):294-304 (2023)

Allele G

OR 1.06

p 3.0e-8

N 376,871

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs12582330

GWAS Catalog Trait Associations (2)

hypothyroidism

autoimmune thyroid disease

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