rs12955644

This variant is located in the YES1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele G

OR 0.31

p 3.0e-22

N 1,028,980

Large GWAS

multi-ancestry

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele G

OR 0.35

p 3.0e-13

N 526,001

Large GWAS

European

Giri A et al. “Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.” Nature Genetics 51(1):51-62 (2019)

Allele G

OR 0.29

p 6.0e-16

N 459,777

Large GWAS

multi-ancestry

diastolic blood pressure

Allele G

OR 0.18

p 5.0e-19

N 1,028,980

Large GWAS

multi-ancestry

pulse pressure measurement

Allele G

OR 0.13

p 5.0e-9

N 1,028,980

Large GWAS

multi-ancestry

About YES1

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

rs12955644

GWAS Catalog Trait Associations (3)

systolic blood pressure

diastolic blood pressure

pulse pressure measurement

About YES1

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