YES1
YES proto-oncogene 1, Src family tyrosine kinase
Summary
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Known Variants34 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs8098380 | 18:721,563 | A/C | downstream gene variant | — |
| rs2510932650 | 18:724,497 | T/C | — | uncertain significance |
| rs2510945897 | 18:732,908 | G/A | — | uncertain significance |
| rs2510951524 | 18:736,862 | C/T | — | uncertain significance |
| rs2510951552 | 18:736,867 | T/C | — | uncertain significance |
| rs781492606 | 18:736,939 | A/G | — | uncertain significance |
| rs147032357 | 18:737,962 | C/T | upstream gene variant | — |
| rs2510959775 | 18:742,950 | G/C | — | uncertain significance |
| rs1310003225 | 18:742,972 | A/G | — | uncertain significance |
| rs778738989 | 18:743,007 | A/C | — | uncertain significance |
| rs752661671 | 18:743,319 | C/T | — | uncertain significance |
| rs757945173 | 18:745,710 | G/C | — | uncertain significance |
| rs1186208968 | 18:745,746 | T/C | — | uncertain significance |
| rs557201481 | 18:745,776 | T/C | — | uncertain significance |
| rs1050998183 | 18:745,837 | G/A | — | uncertain significance |
| rs2305994 | 18:747,825 | A/G | intron variant | — |
| rs766059693 | 18:747,947 | G/A | — | uncertain significance |
| rs758401112 | 18:747,990 | T/C | — | uncertain significance |
| rs117449313 | 18:751,739 | T/G | — | likely benign |
| rs111416313 | 18:751,793 | T/C | — | uncertain significance |
| rs8084192 | 18:753,630 | C/T | intron variant | — |
| rs372333387 | 18:756,587 | C/T | — | uncertain significance |
| rs2510983745 | 18:756,596 | A/G | — | uncertain significance |
| rs201966473 | 18:756,629 | C/T | — | uncertain significance |
| rs563453845 | 18:756,721 | G/A | — | uncertain significance |
| rs202188142 | 18:756,733 | T/C | — | uncertain significance |
| rs12955644 | 18:771,047 | C/T | — | — |
| rs34413141 | 18:777,282 | T/A | regulatory region variant | — |
| rs140010323 | 18:781,732 | C/T | intron variant | — |
| rs9961091 | 18:787,847 | G/A | — | — |
| rs11664027 | 18:807,368 | T/G | intron variant | — |
| rs77284350 | 18:808,322 | G/T | regulatory region variant | — |
| rs9954735 | 18:813,630 | G/A | coding sequence variant | — |
| rs12955961 | 18:814,401 | G/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.