rs12967143

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Howard DM et al. “Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.” Nature Neuroscience 22(3):343-352 (2019)
Allele G
OR 1.03
p 2.0e-27
N 807,553
Meta-analysisLarge GWAS
European
Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele G
OR 0.03
p 6.0e-21
N 1,349,887
Large GWAS
European
Giannakopoulou O et al. “The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.” Jama Psychiatry 78(11):1258-1269 (2021)
Allele G
OR 0.01
p 1.0e-10
N 694,747
Large GWAS
multi-ancestry

wellbeing measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele C
OR 0.01
p 7.0e-16
N 2,083,151
Large GWAS
European

cigarettes per day measurement

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele C
OR 0.01
p 3.0e-12
N 618,489
Large GWAS
European

insomnia

Watanabe K et al. “Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.” Nature Genetics 54(8):1125-1132 (2022)
Allele C
OR 0.01
p 1.0e-8
N 1,216,033
Meta-analysisLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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