rs12972156

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease, family history of Alzheimer’s disease

Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)

Allele G

OR —

p 8.0e-202

N 404,467

Large GWAS

multi-ancestry

Alzheimer disease

Allele G

OR —

p 5.0e-140

N 27,907

Large GWAS

European, African unspecified, Hispanic or Latin American, Asian unspecified, NR

metabolic syndrome

Ho CY et al. “A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population.” Nutrients 16(1) (2023)

Allele C

OR 0.13

p 2.0e-12

N 107,230

Large GWAS

East Asian

cerebral amyloid deposition measurement

Yan Q et al. “Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging.” Molecular Psychiatry 26(1):309-321 (2021)

Allele G

OR 0.17

p 4.0e-12

N 983

Small GWAS

European

health study participation

Adams MJ et al. “Factors associated with sharing e-mail information and mental health survey participation in large population cohorts.” International Journal of Epidemiology 49(2):410-421 (2020)

Allele G

OR 0.01

p 8.0e-12

N 371,428

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs12972156

GWAS Catalog Trait Associations (5)

Alzheimer disease, family history of Alzheimer’s disease

Alzheimer disease

metabolic syndrome

cerebral amyloid deposition measurement

health study participation

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