rs12978472

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GWAS Catalog Trait Associations (14)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

diastolic blood pressure

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele G

OR 0.44

p 1.0e-73

N 1,028,980

Large GWAS

multi-ancestry

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele G

OR 0.04

p 3.0e-32

N 928,679

Large GWAS

multi-ancestry

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele G

OR 0.47

p 1.0e-40

N 526,001

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.04

p 1.0e-23

N 485,677

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.04

p 1.0e-28

N 425,680

Major Consortium StudyLarge GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.03

p 1.0e-24

N 394,642

Large GWAS

European

Yang ML et al. “Sex-specific genetic architecture of blood pressure.” Nature Medicine 30(3):818-828 (2024)

Allele G

OR 0.04

p 3.0e-16

N 174,664

Large GWAS

multi-ancestry

systolic blood pressure

Allele G

OR 0.68

p 2.0e-70

N 1,028,980

Large GWAS

multi-ancestry

Allele G

OR 0.05

p 7.0e-44

N 928,679

Large GWAS

multi-ancestry

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele G

OR 0.84

p 5.0e-44

N 526,001

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.04

p 5.0e-32

N 485,664

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.04

p 2.0e-20

N 425,750

Major Consortium StudyLarge GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.03

p 6.0e-31

N 394,642

Large GWAS

European

Yang ML et al. “Sex-specific genetic architecture of blood pressure.” Nature Medicine 30(3):818-828 (2024)

Allele G

OR 0.04

p 2.0e-30

N 349,328

Large GWAS

multi-ancestry

hypertension

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.11

p 3.0e-48

N 394,626

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.09

p 1.0e-34

N 428,138

Major Consortium StudyLarge GWAS

European

diastolic blood pressure change measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.05

p 1.0e-36

N 425,743

Major Consortium StudyLarge GWAS

European

essential hypertension

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.09

p 6.0e-35

N 427,704

Major Consortium StudyLarge GWAS

European

systolic blood pressure, alcohol drinking

Feitosa MF et al. “Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.” Plos One 13(6):e0198166 (2018)

Allele C

OR —

p 2.0e-34

N 133,355

Large GWAS

multi-ancestry

mean arterial pressure

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.04

p 1.0e-31

N 506,365

Large GWAS

multi-ancestry

hypertension, Antihypertensive use measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.09

p 4.0e-31

N 315,668

Major Consortium StudyLarge GWAS

European

diastolic blood pressure, alcohol drinking

Allele C

OR —

p 4.0e-29

N 133,351

Large GWAS

multi-ancestry

pulse pressure measurement

Allele G

OR 0.29

p 2.0e-25

N 1,028,980

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs12978472

GWAS Catalog Trait Associations (14)

diastolic blood pressure

systolic blood pressure

hypertension

diastolic blood pressure change measurement

essential hypertension

systolic blood pressure, alcohol drinking

mean arterial pressure

hypertension, Antihypertensive use measurement

diastolic blood pressure, alcohol drinking

pulse pressure measurement

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