rs13108218

▶

GWAS Catalog Trait Associations (213)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

serum albumin amount

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele A

OR 0.05

p 4.0e-231

N 928,679

Large GWAS

multi-ancestry

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele A

OR 0.02

p 2.0e-28

N 450,015

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele A

OR 0.04

p 3.0e-84

N 435,807

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.03

p 3.0e-22

N 372,982

Major Consortium StudyLarge GWAS

European

Harrison S et al. “Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank.” Science Advances 7(31) (2021)

Allele A

OR 0.11

p 4.0e-18

N 148,248

Major Consortium StudyLarge GWAS

European

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)

Allele A

OR 0.03

p 2.0e-13

N 136,016

Large GWAS

multi-ancestry

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele A

OR 0.03

p 4.0e-10

N 115,064

Large GWAS

European

triglyceride measurement

Allele A

OR 0.04

p 1.0e-163

N 928,679

Large GWAS

multi-ancestry

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele A

OR 0.03

p 7.0e-57

N 1,320,016

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.03

p 3.0e-28

N 558,637

Major Consortium StudyLarge GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele A

OR 0.03

p 4.0e-53

N 455,659

Large GWAS

multi-ancestry

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele A

OR 0.03

p 3.0e-38

N 450,015

Large GWAS

multi-ancestry

Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)

Allele A

OR 0.03

p 8.0e-50

N 441,016

Large GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.03

p 1.0e-51

N 394,642

Large GWAS

European

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)

Allele A

OR 0.03

p 2.0e-26

N 361,194

Large GWAS

European

Klarin D et al. “Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.” Nature Genetics 50(11):1514-1523 (2018)

Allele A

OR 0.02

p 1.0e-16

N 297,626

Major Consortium StudyLarge GWAS

multi-ancestry

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)

Allele A

OR 0.03

p 1.0e-11

N 136,016

Large GWAS

multi-ancestry

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele A

OR 0.04

p 4.0e-19

N 115,082

Large GWAS

European

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele A

OR 0.04

p 2.0e-15

N 88,329

Large GWAS

European

de Vries PS et al. “Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.” American Journal of Epidemiology 188(6):1033-1054 (2019)

Allele A

OR —

β 0.020

p 1.0e-12

N 71,394

Large GWAS

multi-ancestry

platelet count

Allele A

OR 0.03

p 1.0e-82

N 928,679

Large GWAS

multi-ancestry

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.02

p 3.0e-26

N 394,642

Large GWAS

European

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)

Allele A

OR —

p 2.0e-12

N 235,256

Large GWAS

European

total cholesterol measurement

Allele A

OR 0.03

p 2.0e-79

N 928,679

Large GWAS

multi-ancestry

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele A

OR 0.03

p 2.0e-49

N 1,320,016

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele A

OR 0.02

p 8.0e-25

N 480,086

Large GWAS

multi-ancestry

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.02

p 2.0e-25

N 394,642

Large GWAS

European

glycoprotein measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.04

p 6.0e-75

N 450,015

Large GWAS

multi-ancestry

Yuan F et al. “Blood metabolic biomarkers and colorectal cancer risk: results from large prospective cohort and Mendelian randomisation analyses.” British Journal of Cancer 133(1):94-103 (2025)

Allele G

OR 0.04

p 3.0e-32

N 199,732

Large GWAS

European

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.04

p 5.0e-20

N 115,082

Large GWAS

European

Allele G

OR 0.04

p 1.0e-17

N 88,329

Large GWAS

European

concentration of small HDL particles measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.04

p 3.0e-73

N 450,015

Large GWAS

multi-ancestry

triglycerides to total lipids in very large HDL percentage

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.03

p 1.0e-70

N 450,015

Large GWAS

multi-ancestry

Allele G

OR 0.04

p 3.0e-16

N 88,307

Large GWAS

European

calcium measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.04

p 2.0e-67

N 399,133

Large GWAS

multi-ancestry

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.03

p 5.0e-59

N 394,642

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.03

p 7.0e-17

N 355,605

Major Consortium StudyLarge GWAS

multi-ancestry

Young WJ et al. “Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank.” Circulation. Genomic and Precision Medicine 14(3):e003231 (2021)

Allele G

OR 0.00

p 3.0e-51

N 305,349

Major Consortium StudyLarge GWAS

European

total lipids in small HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.04

p 8.0e-66

N 450,015

Large GWAS

multi-ancestry

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)

Allele G

OR 0.03

p 2.0e-14

N 136,016

Large GWAS

multi-ancestry

Allele G

OR 0.04

p 2.0e-15

N 88,329

Large GWAS

European

phospholipids:total lipids ratio

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.03

p 8.0e-65

N 450,015

Large GWAS

multi-ancestry

Allele G

OR 0.04

p 2.0e-15

N 88,329

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs13108218

GWAS Catalog Trait Associations (213)

serum albumin amount

triglyceride measurement

platelet count

total cholesterol measurement

glycoprotein measurement

concentration of small HDL particles measurement

triglycerides to total lipids in very large HDL percentage

calcium measurement

total lipids in small HDL measurement

phospholipids:total lipids ratio

Community Wiki

Comments