rs13262595

This variant is located in the TSNARE1 gene.

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GWAS Catalog Trait Associations (12)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

reaction time measurement

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele A
OR 0.02
p 1.0e-18
N 404,449
Large GWAS
European

Anxiety

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele A
OR 0.02
p 3.0e-13
N 348,219
Meta-analysisLarge GWAS
European

intelligence

Davies G et al. “Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.” Nature Communications 9(1):2098 (2018)
Allele A
OR 7.25
p 4.0e-13
N 300,486
Large GWAS
European
Savage JE et al. “Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.” Nature Genetics 50(7):912-919 (2018)
Allele A
OR 6.13
p 9.0e-10
N 269,867
Meta-analysisLarge GWAS
European
Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele A
OR 0.02
p 2.0e-12
N 254,641
Large GWAS
European
Hill WD et al. “A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.” Molecular Psychiatry 24(2):169-181 (2019)
Allele A
OR 0.02
p 3.0e-9
N 248,482
Large GWAS
European

health study participation

Adams MJ et al. “Factors associated with sharing e-mail information and mental health survey participation in large population cohorts.” International Journal of Epidemiology 49(2):410-421 (2020)
Allele G
OR 0.01
p 1.0e-9
N 371,428
Large GWAS
European
Tyrrell J et al. “Genetic predictors of participation in optional components of UK Biobank.” Nature Communications 12(1):886 (2021)
Allele G
OR 0.97
p 8.0e-9
N 294,787
Major Consortium StudyLarge GWAS
European

anxiety measurement

Thorp JG et al. “Symptom-level modelling unravels the shared genetic architecture of anxiety and depression.” Nature Human Behaviour 5(10):1432-1442 (2021)
Allele A
OR 0.01
p 2.0e-9
N 136,957
Large GWAS
European

post-traumatic stress disorder symptom measurement

Stein MB et al. “Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.” Nature Genetics 53(2):174-184 (2021)
Allele G
OR 0.28
p 2.0e-9
N 186,689
Major Consortium StudyLarge GWAS
European

taste liking measurement

May-Wilson S et al. “Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits.” Nature Communications 13(1):2743 (2022)
Allele G
OR 0.02
p 2.0e-9
N 154,673
Large GWAS
European

neuroticism measurement

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele A
OR 5.83
p 6.0e-9
N 449,484
Meta-analysisLarge GWAS
European

About TSNARE1

Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in synaptic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

View all TSNARE1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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