rs13380830

This is a intron variant variant in the RAB5C gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hypothyroidism

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele G

OR 0.05

p 8.0e-29

N 1,786,062

Large GWAS

European

Thyroid preparation use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.09

p 2.0e-15

N 484,308

Large GWAS

multi-ancestry

Hashimoto's thyroiditis

Allele G

OR 0.10

p 6.0e-9

N 1,420,658

Large GWAS

European

About RAB5C

Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]

View all RAB5C variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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