rs1375131

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

total cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele C
OR 0.02
p 7.0e-27
N 1,320,016
Large GWAS
European

low density lipoprotein cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele C
OR 0.02
p 1.0e-22
N 1,320,016
Large GWAS
European

metabolite measurement

Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele C
OR 0.11
p 8.0e-13
N 4,903
Large GWAS
European

non-high density lipoprotein cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele T
OR 0.02
p 4.0e-12
N 1,320,016
Large GWAS
European

gut microbiome measurement

Kurilshikov A et al. “Large-scale association analyses identify host factors influencing human gut microbiome composition.” Nature Genetics 53(2):156-165 (2021)
Allele C
OR 8.68
p 4.0e-18
N 18,340
Large GWAS
multi-ancestry
Qin Y et al. “Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort.” Nature Genetics 54(2):134-142 (2022)
Allele C
OR 0.07
p 4.0e-8
N 5,959
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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