rs144198753

This is a intergenic variant variant in the LOC105377343 gene.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

alcohol consumption quality

Brazel DM et al. “Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.” Biological Psychiatry 85(11):946-955 (2019)
Allele T
OR 0.23
p 4.0e-68
N 357,854
Meta-analysisLarge GWAS
European
Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)
Allele T
OR 0.04
p 1.0e-12
N 941,280
Large GWAS
European
Thompson A et al. “Functional validity, role, and implications of heavy alcohol consumption genetic loci.” Science Advances 6(3):eaay5034 (2020)
Allele T
OR 10.99
p 4.0e-29
N 125,249
Large GWAS
European
Clarke TK et al. “Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).” Molecular Psychiatry 22(10):1376-1384 (2017)
Allele T
OR 0.03
p 5.0e-16
N 112,117
Major Consortium StudyLarge GWAS
European

low density lipoprotein cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele T
OR 0.06
p 1.0e-10
N 1,320,016
Large GWAS
European

diet measurement

Cole JB et al. “Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations.” Nature Communications 11(1):1467 (2020)
Allele C
OR 0.06
p 1.0e-8
N 449,210
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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