rs1458038

This is a intergenic variant variant in the LOC124900725 gene.

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GWAS Catalog Trait Associations (97)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hematocrit

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele T
OR 0.02
p 1.0e-32
N 562,259
Large GWAS
European
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.02
p 1.0e-12
N 407,852
Major Consortium StudyLarge GWAS
European

serum creatinine amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 4.0e-28
N 600,139
Major Consortium StudyLarge GWAS
multi-ancestry

mean arterial pressure

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)
Allele T
OR 0.60
p 4.0e-27
N 130,777
Large GWAS
multi-ancestry
Wain LV et al. “Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.” Nature Genetics 43(10):1005-11 (2011)
Allele T
OR 0.40
p 3.0e-14
N 74,064
Large GWAS
European
Sofer T et al. “Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos.” Scientific Reports 7(1):10348 (2017)
Allele T
OR 0.97
p 5.0e-8
N 12,278
Large GWAS
multi-ancestry

systolic blood pressure

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)
Allele T
OR 0.84
p 3.0e-26
N 130,777
Large GWAS
multi-ancestry
Ehret GB et al. “The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.” Nature Genetics 48(10):1171-1184 (2016)
Allele T
OR 0.66
p 5.0e-24
N 201,529
Large GWAS
European
Wain LV et al. “Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.” Hypertension (dallas, Tex. : 1979) 70(3):e4-e19 (2017)
Allele T
OR 0.66
p 1.0e-16
N 150,134
Large GWAS
multi-ancestry
Kato N et al. “Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.” Nature Genetics 47(11):1282-1293 (2015)
Allele T
OR 0.97
p 5.0e-8
N 99,994
Large GWAS
multi-ancestry
Ehret GB et al. “Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.” Nature 478(7367):103-9 (2011)
Allele T
OR 0.71
p 2.0e-23
N 69,395
Large GWAS
European
Franceschini N et al. “Variant Discovery and Fine Mapping of Genetic Loci Associated with Blood Pressure Traits in Hispanics and African Americans.” Plos One 11(10):e0164132 (2016)
Allele T
OR 1.37
p 9.0e-10
N 38,450
Large GWAS
multi-ancestry

phospholipids in very small VLDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele T
OR 0.02
p 2.0e-22
N 450,015
Large GWAS
multi-ancestry

free cholesterol in very small VLDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele T
OR 0.02
p 3.0e-22
N 450,015
Large GWAS
multi-ancestry

hypertension

Jeong H et al. “Identifying Interactions between Dietary Sodium, Potassium, Sodium-Potassium Ratios, and FGF5 rs16998073 Variants and Their Associated Risk for Hypertension in Korean Adults.” Nutrients 12(7) (2020)
Allele T
OR 1.26
p 3.0e-22
N 17,736
Large GWAS
East Asian
Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)
Allele T
OR 0.13
p 2.0e-20
N 50,792
Large GWAS
multi-ancestry

total lipids in very small VLDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele T
OR 0.02
p 7.0e-22
N 450,015
Large GWAS
multi-ancestry

concentration of very small VLDL particles

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele T
OR 0.02
p 1.0e-21
N 450,015
Large GWAS
multi-ancestry

apolipoprotein B measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele T
OR 0.02
p 1.0e-20
N 450,015
Large GWAS
multi-ancestry
Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)
Allele T
OR 0.02
p 6.0e-13
N 439,214
Large GWAS
European
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Research that mentions this SNP (1)

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Genome-wide association study of endometrial cancer in E2C2
AssociationN=23,420Immaculata De Vivo et al.(2014)· Human Genetics

Genome-wide association study of endometrial cancer (7,077 cases, 16,343 controls) identifying replication of the known HNF1B locus (rs4430796, OR=0.82, P=4.3×10⁻¹¹) and a novel genome-wide significant association at the RNASET2 locus (rs9459805, OR=1.19, P=1.11×10⁻⁵). A suggestive locus at PRLR (prolactin receptor) was also identified.

Traits studied:Endometrial cancerEndometrioid endometrial cancerSerous endometrial cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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