rs148583745
This is a upstream gene variant variant in the GMEB2 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
uterine fibroid
Kim J et al. “Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.” Nature Communications 16(1):2273 (2025)
Allele A
OR 0.13
p 5.0e-12
N 709,132
Meta-analysisLarge GWAS
multi-ancestry
idiopathic pulmonary fibrosis
Zhou W et al. “Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.” Cell Genomics 2(10):100192 (2022)
Allele G
OR 0.35
p 7.0e-10
N 1,254,748
Meta-analysisLarge GWAS
multi-ancestry
About GMEB2
This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
View all GMEB2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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