rs1487441

This is a intron variant variant.

▶

GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

intelligence

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele G
OR 0.03
p 1.0e-26
N 254,641
Large GWAS
European

free cholesterol in very large HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 1.0e-23
N 450,015
Large GWAS
multi-ancestry

triglycerides to total lipids in very large HDL percentage

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.01
p 6.0e-15
N 450,015
Large GWAS
multi-ancestry

hematocrit

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.01
p 5.0e-14
N 394,642
Large GWAS
European

cholesterol to total lipids in large HDL percentage

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.01
p 2.0e-13
N 450,015
Large GWAS
multi-ancestry

health study participation

Adams MJ et al. “Factors associated with sharing e-mail information and mental health survey participation in large population cohorts.” International Journal of Epidemiology 49(2):410-421 (2020)
Allele A
OR 0.01
p 1.0e-11
N 371,417
Large GWAS
European

self reported educational attainment

Rietveld CA et al. “Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.” Proceedings of the National Academy of Sciences of the United States of America 111(38):13790-4 (2014)
Allele A
OR —
β 0.026
p 2.0e-9
N 106,736
Large GWAS
European

bipolar disorder

Hou L et al. “Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.” Human Molecular Genetics 25(15):3383-3394 (2016)
Allele G
OR 1.12
p 3.0e-8
N 34,950
Large GWAS
European

creativity measurement

Li WD et al. “A genome-wide association study of occupational creativity and its relations with well-being and career success.” Communications Biology 7(1):1092 (2024)
Allele G
OR 0.05
p 2.0e-12
N 125,803
Large GWAS
European
▶

Research that mentions this SNP (1)

▶
Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment
AssociationN=20,495Joey W. Trampush et al.(2015)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A GWAS replication study demonstrating that rs1906252 (6q16.1, in an intron of lincRNA RP11-436D23.1) is independently associated with general cognitive ability (g factor) across 20,495 COGENT participants (beta=0.031, p=1.47×10⁻⁴). The minor A allele was associated with higher cognitive scores; meta-analysis combining COGENT and SSGAC (43,381 samples) yielded p=4.94×10⁻⁷. The locus was previously identified in an educational attainment GWAS, confirming shared genetic architecture between cognitive ability and educational outcomes.

Traits studied:Cognitive functionEducational attainmentGeneral cognitive abilityProcessing speed
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…