rs1713222

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

low density lipoprotein cholesterol measurement

Oni-Orisan A et al. “The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.” Npj Genomic Medicine 5:1 (2020)

Allele A

OR —

β 0.027

p 1.0e-26

N 34,874

Large GWAS

multi-ancestry

triglycerides:total lipids ratio, blood VLDL cholesterol amount

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)

Allele A

OR 0.05

p 1.0e-14

N 126,671

Large GWAS

multi-ancestry

response to statin, LDL cholesterol change measurement

Oni-Orisan A et al. “The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.” Npj Genomic Medicine 5:1 (2020)

Allele A

OR —

β 0.013

p 5.0e-8

N 34,874

Large GWAS

multi-ancestry

free cholesterol:total lipids ratio, blood VLDL cholesterol amount

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)

Allele A

OR 0.04

p 9.0e-11

N 136,016

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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