rs17681684
This is a protein-altering variant in the GLP2R gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
citrulline measurement
Lotta LA et al. “A cross-platform approach identifies genetic regulators of human metabolism and health.” Nature Genetics 53(1):54-64 (2021)
Allele A
OR 9.62
p 6.0e-22
N 30,940
Large GWAS
European
total cholesterol measurement
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele A
OR 0.01
p 6.0e-11
N 1,320,016
Large GWAS
European
glucose-dependent insulinotropic peptide measurement, glucose tolerance test
Almgren P et al. “Genetic determinants of circulating GIP and GLP-1 concentrations.” Jci Insight 2(21) (2017)
Allele A
OR 0.06
p 1.0e-9
N 3,344
Large GWAS
European
About GLP2R
This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
View all GLP2R variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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