rs188911996
This is a intron variant variant in the KDM1B gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Alzheimer disease, age at onset
Herold C et al. “Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.” Molecular Psychiatry 21(11):1608-1612 (2016)
Allele A
OR 5.58
p 2.0e-8
N 4,527
Large GWAS
European
About KDM1B
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]
View all KDM1B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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