rs1998948
This is a regulatory region variant variant in the GPR157 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
eye color
Simcoe M et al. “Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color.” Science Advances 7(11) (2021)
Allele T
OR —
p 1.0e-9
N 157,485
Large GWAS
multi-ancestry
About GPR157
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and radial glial cell differentiation. Predicted to be located in ciliary membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all GPR157 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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