rs2067819

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

triglyceride measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.02
p 1.0e-16
N 455,659
Large GWAS
multi-ancestry

polyunsaturated fatty acids to monounsaturated fatty acids ratio

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 4.0e-16
N 450,015
Large GWAS
multi-ancestry

saturated fatty acids to total fatty acids percentage

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele A
OR 0.02
p 9.0e-15
N 450,015
Large GWAS
multi-ancestry

chloride level

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.02
p 1.0e-13
N 412,569
Major Consortium StudyLarge GWAS
European

blood urea nitrogen amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.02
p 3.0e-13
N 418,647
Major Consortium StudyLarge GWAS
European

mean corpuscular hemoglobin concentration

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.02
p 5.0e-13
N 583,883
Major Consortium StudyLarge GWAS
multi-ancestry

age at menopause

Zhang L et al. “Joint Genome-Wide Association Analyses Identified 49 Novel Loci For Age at Natural Menopause.” The Journal of Clinical Endocrinology and Metabolism 106(9):2574-2591 (2021)
Allele A
OR —
β 0.090
p 4.0e-9
N 225,080
Large GWAS
multi-ancestry

low density lipoprotein cholesterol measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.02
p 4.0e-11
N 578,955
Major Consortium StudyLarge GWAS
multi-ancestry

triglyceride:HDL cholesterol ratio

Oliveri A et al. “Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.” Nature Genetics 56(2):212-221 (2024)
Allele G
OR 0.04
p 4.0e-16
N 185,749
Major Consortium StudyLarge GWAS
European
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Research that mentions this SNP (1)

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Association of peroxisome proliferator-activated receptor gamma polymorphisms with inflammatory bowel disease in a Hungarian cohort
AssociationN=1,164Szilard Poliska et al.(2012)· Inflammatory Bowel Diseases

This case-control association study examined four PPARG polymorphisms in a Hungarian IBD cohort (575 CD, 103 UC patients, 486 controls). The Pro12Ala variant (rs1801282) showed significant protective effect in CD homozygotes (OR=0.33, P=0.03), and haplotype analysis revealed the GAGG haplotype was protective in both CD and UC (OR=0.14 in UC, P=3.78×10⁻⁵), while the GAGC haplotype increased UC risk (OR=6.70, P=3.85×10⁻¹⁰).

Traits studied:Crohn's diseaseInflammatory bowel diseaseUlcerative colitis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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