rs2115630
This is a intron variant variant in the ALPK3 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
QT interval
Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)
Allele T
OR 0.03
p 1.0e-20
N 252,730
Large GWAS
European, African unspecified, Hispanic or Latin American, South East Asian, South Asian
JT interval
Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)
Allele T
OR 0.02
p 1.0e-16
N 252,730
Large GWAS
European, African unspecified, Hispanic or Latin American, South East Asian, South Asian
P wave terminal force measurement
Christophersen IE et al. “Fifteen Genetic Loci Associated With the Electrocardiographic P Wave.” Circulation. Cardiovascular Genetics 10(4) (2017)
Allele T
OR 85.00
p 6.0e-10
N 40,733
Large GWAS
multi-ancestry
About ALPK3
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in cardiac muscle cell development. Predicted to be active in nucleus. Implicated in hypertrophic cardiomyopathy 27. [provided by Alliance of Genome Resources, Jul 2025]
View all ALPK3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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