rs2179744

This variant is located in the L3MBTL2 gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroticism measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele A
OR 0.01
p 2.0e-14
N 523,783
Large GWAS
European

depressive symptom measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele A
OR 0.01
p 3.0e-14
N 1,067,913
Large GWAS
European
Turley P et al. “Multi-trait analysis of genome-wide association summary statistics using MTAG.” Nature Genetics 50(2):229-237 (2018)
Allele A
OR 0.01
p 2.0e-8
N 354,862
Large GWAS
European

major depressive disorder

Hyde CL et al. “Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.” Nature Genetics 48(9):1031-6 (2016)
Allele G
OR 0.04
p 6.0e-11
N 326,113
Large GWAS
European

wellbeing measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele A
OR 0.01
p 4.0e-10
N 410,603
Large GWAS
European

About L3MBTL2

Enables methylated histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including ectoderm development; stem cell differentiation; and stem cell proliferation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

View all L3MBTL2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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