rs2269426

This is a regulatory region variant variant in the TNXB gene.

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

worry measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 7.87
p 4.0e-15
N 372,869
Large GWAS
European

neuroticism measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 7.71
p 1.0e-14
N 380,506
Large GWAS
European
Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele A
OR 0.01
p 3.0e-11
N 523,783
Large GWAS
European

inhibin beta C chain measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.04
p 2.0e-14
N 47,745
Large GWAS
European

level of protein disulfide isomerase CRELD1 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.03
p 3.0e-14
N 47,745
Large GWAS
European

neurotic disorder

Cai N et al. “Minimal phenotyping yields genome-wide association signals of low specificity for major depression.” Nature Genetics 52(4):437-447 (2020)
Allele A
OR 0.01
p 3.0e-12
N 274,107
Large GWAS
European

depressive symptom measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele A
OR 0.01
p 4.0e-11
N 1,067,913
Large GWAS
European

ulcerative colitis

Khrom M et al. “Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.” Inflammatory Bowel Diseases 29(10):1622-1632 (2023)
Allele A
OR 0.87
p 4.0e-11
N 24,307
Large GWAS
European

sex interaction measurement, ulcerative colitis

Khrom M et al. “Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.” Inflammatory Bowel Diseases 29(10):1622-1632 (2023)
Allele A
OR —
p 1.0e-10
N 53,848
Large GWAS
European

About TNXB

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

View all TNXB variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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