rs229195
This variant is located in the G2E3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
amyotrophic lateral sclerosis
van Rheenen W et al. “Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.” Nature Genetics 53(12):1636-1648 (2021)
Allele A
OR 0.09
p 9.0e-15
N 138,086
Large GWAS
European
About G2E3
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in apoptotic process and protein ubiquitination. Predicted to act upstream of or within blastocyst development; negative regulation of intrinsic apoptotic signaling pathway; and protein polyubiquitination. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
View all G2E3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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