rs2297441
This variant is located in the TNFRSF6B gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
ulcerative colitis
▶Research that mentions this SNP (1)
▶Genetic analysis of the relation of telomere length‐related gene (RTEL1) and coronary heart disease riskAssociationN=1,199Shijuan Lu et al.(2019)· Molecular Genetics & Genomic Medicine
This case-control study examined 5 SNPs in the RTEL1 gene (regulator of telomere elongation helicase 1) in 596 coronary heart disease (CHD) patients and 603 healthy controls from a Chinese Han population. Two SNPs showed protective associations: rs6010620 (OR = 0.78, 95% CI = 0.65-0.93, p = 0.005) and rs4809324 (OR = 0.08, 95% CI = 0.04-0.16, p = 2.74E-21). Haplotype analysis revealed the 'GTT' haplotype of three RTEL1 SNPs was associated with significantly decreased CHD risk (OR = 0.03, 95% CI = 0.01-0.12, p < 0.0001).
About TNFRSF6B
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
View all TNFRSF6B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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