TNFRSF6B

TNF receptor superfamily member 6b

Summary

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Known Variants326 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs3208008	20:62,326,110	A/C	missense variant	benign
rs115303435	20:62,326,159	G/A	missense variant	likely benign
rs786205702	20:62,326,446	A/C	missense variant	pathogenic
rs587777037	20:62,326,911	T/C	missense variant	pathogenic
rs201540674	20:62,326,972	G/A	missense variant	pathogenic
rs2297441	20:62,327,582	G/C	—	—
rs2517213269	20:62,328,127	G/T	—	uncertain significance
rs781657376	20:62,328,128	C/T	—	uncertain significance
rs748534320	20:62,328,129	G/C	—	likely benign
rs2517213315	20:62,328,133	G/A	—	uncertain significance
rs144447293	20:62,328,136	G/A	—	likely benign
rs2090990466	20:62,328,139	C/A	—	uncertain significance
rs990360819	20:62,328,145	C/G	—	uncertain significance
rs532783203	20:62,328,149	C/T	—	uncertain significance
rs774148576	20:62,328,150	G/A	—	likely benign
rs2517213486	20:62,328,152	T/G	—	uncertain significance
rs1203834199	20:62,328,153	G/C	—	likely benign
rs1261654402	20:62,328,154	C/G	—	uncertain significance
rs759554990	20:62,328,160	C/T	—	likely benign
rs771737847	20:62,328,162	G/A	—	likely benign
rs760554622	20:62,328,170	C/T	—	uncertain significance
rs2517213691	20:62,328,172	C/T	—	likely benign
rs750734718	20:62,328,175	C/T	—	uncertain significance
rs763121875	20:62,328,176	C/T	—	uncertain significance
rs374556929	20:62,328,180	C/G	—	likely benign
rs1343467616	20:62,328,181	C/T	—	likely benign
rs368965127	20:62,328,182	T/C	—	uncertain significance
rs2517213834	20:62,328,185	T/C	—	uncertain significance
rs371926409	20:62,328,188	C/T	—	uncertain significance
rs140974898	20:62,328,189	G/A	—	likely benign
rs778530785	20:62,328,190	G/A	—	uncertain significance
rs375326054	20:62,328,194	C/T	—	conflicting classifications of pathogenicity
rs533744128	20:62,328,195	G/A	—	likely benign
rs2517213958	20:62,328,198	T/G	—	likely benign
rs571944193	20:62,328,202	C/T	—	likely benign
rs370000278	20:62,328,203	G/A	—	uncertain significance
rs61760055	20:62,328,205	G/A	—	benign
rs766532363	20:62,328,209	T/C	—	conflicting classifications of pathogenicity
rs768009041	20:62,328,221	C/T	—	uncertain significance
rs367883678	20:62,328,235	C/T	—	uncertain significance
rs144974329	20:62,328,236	G/A	—	likely benign
rs745329328	20:62,328,240	C/T	—	likely benign
rs372122002	20:62,328,241	G/T	—	uncertain significance
rs1024186135	20:62,328,246	G/C	—	uncertain significance
rs768549687	20:62,328,249	A/G	—	likely benign
rs1251326230	20:62,328,250	G/A	—	uncertain significance
rs776519069	20:62,328,251	G/C	—	uncertain significance
rs747925412	20:62,328,252	G/A	—	likely benign
rs771116925	20:62,328,255	G/A	—	likely benign
rs774448942	20:62,328,256	C/T	—	conflicting classifications of pathogenicity
rs572993898	20:62,328,257	G/T	—	uncertain significance
rs775941793	20:62,328,262	G/A	—	uncertain significance
rs2257440	20:62,328,267	C/T	—	benign
rs764931903	20:62,328,268	G/A	—	uncertain significance
rs2090993746	20:62,328,275	G/A	—	uncertain significance
rs1568729901	20:62,328,280	C/T	—	uncertain significance
rs2090993939	20:62,328,285	C/T	—	likely benign
rs754926532	20:62,328,287	C/T	—	uncertain significance
rs2090994224	20:62,328,298	C/T	—	uncertain significance
rs769534113	20:62,328,299	G/A	—	likely benign
rs956816954	20:62,328,301	C/T	—	uncertain significance
rs1415609067	20:62,328,302	C/T	—	uncertain significance
rs538491653	20:62,328,303	G/A	—	likely benign
rs2145486990	20:62,328,305	G/A	—	uncertain significance
rs746113298	20:62,328,307	C/T	—	uncertain significance
rs376360925	20:62,328,308	G/A	—	uncertain significance
rs775494393	20:62,328,310	C/T	—	uncertain significance
rs61760056	20:62,328,311	G/A	—	uncertain significance
rs777066541	20:62,328,312	A/C	—	likely benign
rs940237971	20:62,328,313	G/C	—	uncertain significance
rs2145487089	20:62,328,316	A/G	—	uncertain significance
rs1279029772	20:62,328,319	C/T	—	uncertain significance
rs765564244	20:62,328,324	G/A	—	likely benign
rs200678279	20:62,328,326	C/T	—	uncertain significance
rs781260690	20:62,328,332	G/A	—	uncertain significance
rs748099477	20:62,328,333	C/T	—	likely benign
rs755903692	20:62,328,335	C/T	—	uncertain significance
rs140118504	20:62,328,336	G/A	—	likely benign
rs755686943	20:62,328,338	G/A	—	uncertain significance
rs895203526	20:62,328,342	A/G	—	likely benign
rs1224394739	20:62,328,343	C/G	—	uncertain significance
rs561972262	20:62,328,344	C/T	—	uncertain significance
rs747082620	20:62,328,345	G/A	—	likely benign
rs1299161540	20:62,328,346	C/T	—	uncertain significance
rs371940556	20:62,328,347	G/A	—	uncertain significance
rs2090995658	20:62,328,350	A/G	—	uncertain significance
rs2517215701	20:62,328,355	A/C	—	uncertain significance
rs770358515	20:62,328,357	G/T	—	likely benign
rs2090995888	20:62,328,360	G/A	—	likely benign
rs2145487307	20:62,328,371	A/T	—	uncertain significance
rs142858927	20:62,328,372	C/T	—	benign
rs759110165	20:62,328,373	C/T	—	likely benign
rs2738787	20:62,328,375	G/A	—	likely benign
rs755954406	20:62,328,379	C/T	—	uncertain significance
rs1362783976	20:62,328,381	C/T	—	likely benign
rs1269571612	20:62,328,385	C/T	—	uncertain significance
rs753507208	20:62,328,386	G/A	—	uncertain significance
rs757105777	20:62,328,387	C/G	—	likely benign
rs2090996589	20:62,328,394	A/G	—	uncertain significance
rs780254251	20:62,328,395	A/G	—	uncertain significance

Showing 100 of 326 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.