rs2352974

This is a downstream gene variant variant in the TRAIP gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

intelligence

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.03
p 2.0e-31
N 254,641
Large GWAS
European
Savage JE et al. “Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.” Nature Genetics 50(7):912-919 (2018)
Allele C
OR 11.21
p 4.0e-29
N 269,867
Meta-analysisLarge GWAS
European

waist-hip ratio

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele T
OR 0.02
p 6.0e-18
N 316,772
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (1)

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Genome‐wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type
Meta-analysisN=9,917Elaine K. Green et al.(2017)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This meta-analysis of Research Diagnostic Criteria Schizoaffective Disorder Bipolar type (RDC-SABP) identified a genome-wide significant locus at rs2352974 in the TRAIP gene on chromosome 3p21.31 (P=4.37×10⁻⁸, OR=0.67). By combining WTCCC data (n=279 cases, n=2,938 controls) with an independent ImmunoChip replication sample (n=144 cases, n=6,559 controls), the study analyzed 10 SNPs previously associated with RDC-SABP. The TRAIP locus was not genome-wide significant in larger bipolar disorder or schizophrenia consortia datasets, suggesting it may represent a relatively specific genetic risk factor for the bipolar subtype of schizoaffective disorder.

Traits studied:RDC-SABPSchizoaffective Disorder Bipolar type
PubMedDOIMetascience Observatory

About TRAIP

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]

View all TRAIP variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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