rs2425752

This variant is located in the NCOA5 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroticism measurement

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele T
OR 7.21
p 5.0e-13
N 449,484
Meta-analysisLarge GWAS
European

multiple sclerosis

Sawcer S et al. “Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.” Nature 476(7359):214-9 (2011)
Allele A
OR 1.11
p 5.0e-10
N 26,621
Large GWAS
European

Hodgkins lymphoma

Sud A et al. “Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.” Blood 132(19):2040-2052 (2018)
Allele T
OR 1.15
p 2.0e-8
N 27,750
Large GWAS
European

anxiety disorder

Friligkou E et al. “Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study.” Nature Genetics 56(10):2036-2045 (2024)
Allele T
OR —
β 0.013
p 3.0e-8
N 1,096,458
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B
AssociationN=6,033Jiang DK et al.(2015)· Hepatology

A genome-wide association study of 83 plasma proteins relevant to cardiovascular disease in 3,394 European subjects identified 79 genome-wide significant loci (p<5e-8), with 55 replicating in independent cohorts (n=2,639). Using eQTL analysis and network methods, the authors proposed plausible causal mechanisms for 25 trans-acting loci including post-translational regulation of KITLG by MMP9 and several receptor-ligand pairs. Multiple loci showed evidence of causal association with coronary artery disease risk.

Traits studied:AtherosclerosisCoronary artery diseasePlaque rupturePlasma protein levels (83 cardiovascular disease-related proteins)Thrombosis
PubMedDOIMetascience Observatory

About NCOA5

This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]

View all NCOA5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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