rs2494938
This is a intron variant variant in the LRFN2 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
lung carcinoma, squamous cell carcinoma, gastric carcinoma
Jin G et al. “Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.” American Journal of Human Genetics 91(5):928-34 (2012)
Allele A
OR 1.15
p 1.0e-12
N 9,374
Large GWAS
East Asian
squamous cell carcinoma
Jin G et al. “Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.” American Journal of Human Genetics 91(5):928-34 (2012)
Allele A
OR 1.18
p 5.0e-9
N 9,374
Large GWAS
East Asian
About LRFN2
Predicted to be involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cell surface; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]
View all LRFN2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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