rs2517601
This is a intron variant variant in the TRIM31 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
major depressive disorder
Howard DM et al. “Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.” Nature Communications 9(1):1470 (2018)
Allele C
OR 0.01
p 5.0e-13
N 322,580
Major Consortium StudyLarge GWAS
European
glomerular filtration rate
Hellwege JN et al. “Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program.” Nature Communications 10(1):3842 (2019)
Allele C
OR 0.96
p 4.0e-12
N 91,729
Major Consortium StudyLarge GWAS
multi-ancestry
About TRIM31
This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
View all TRIM31 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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