rs2745803

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hypothyroidism

Rand SA et al. “Genome-wide association study and polygenic risk prediction of hypothyroidism.” Nature Genetics 57(12):3007-3015 (2025)

Allele G

OR 0.05

p 2.0e-17

N 1,178,661

Large GWAS

European

Figuerêdo J et al. “Uncovering the shared genetic components of thyroid disorders and reproductive health.” European Journal of Endocrinology 191(2):211-222 (2024)

Allele G

OR 1.06

p 4.0e-9

N 691,986

Large GWAS

European

Mathieu S et al. “Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms.” Iscience 25(9):104992 (2022)

Allele G

OR 0.06

p 8.0e-10

N 494,577

Large GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.08

p 6.0e-12

N 394,626

Large GWAS

European

autoimmune thyroid disease

Saevarsdottir S et al. “FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.” Nature 584(7822):619-623 (2020)

Allele A

OR 1.09

p 2.0e-12

N 754,406

Large GWAS

European

Zeng Y et al. “Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.” The American Journal of Psychiatry 180(4):294-304 (2023)

Allele A

OR 0.93

p 2.0e-8

N 376,871

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs2745803

GWAS Catalog Trait Associations (2)

hypothyroidism

autoimmune thyroid disease

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