rs2943641

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sex hormone-binding globulin measurement

Ruth KS et al. “Using human genetics to understand the disease impacts of testosterone in men and women.” Nature Medicine 26(2):252-258 (2020)
Allele T
OR 0.01
p 1.0e-65
N 368,929
Large GWAS
European

adiponectin measurement

Spracklen CN et al. “Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.” American Journal of Human Genetics 105(1):15-28 (2019)
Allele C
OR —
β 0.057
p 1.0e-21
N 67,739
Large GWAS
multi-ancestry

triglyceride measurement, blood VLDL cholesterol amount

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.04
p 4.0e-17
N 136,016
Large GWAS
multi-ancestry

type 2 diabetes mellitus

Rung J et al. “Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.” Nature Genetics 41(10):1110-5 (2009)
Allele C
OR 1.19
p 9.0e-12
N 1,376
Large GWAS
European

high density lipoprotein cholesterol measurement

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)
Allele T
OR —
β 0.039
p 2.0e-23
N 94,674
Large GWAS
multi-ancestry

triglyceride measurement

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)
Allele T
OR —
β 0.041
p 1.0e-21
N 94,674
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight
AssociationN=4,213Andersson EA et al.(2010)· Diabetologia

This association study of 4,213 Danish individuals examined 25 type 2 diabetes risk variants and their association with birthweight. The study found that type 2 diabetes risk alleles near ADCY5 (rs11708067, β = -33 g, p = 0.004), CDKAL1 (rs7756992, β = -22 g, p = 0.04), and HHEX-IDE (rs1111875, β = -16 g in meta-analysis, p = 8×10⁻⁵, n = 25,164) were associated with reduced birthweight, supporting the fetal insulin hypothesis. Meta-analyses confirmed these associations and showed no strong general effect on birthweight from the 25 common type 2 diabetes risk alleles combined.

Traits studied:Birth lengthBirthweightPonderal indexType 2 diabetes
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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