rs2972147
▶GWAS Catalog Trait Associations (12)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (12)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
LDL particle size
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele C
OR 0.03
p 2.0e-38
N 450,015
Large GWAS
multi-ancestry
leucine measurement
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele C
OR 0.03
p 4.0e-35
N 450,015
Large GWAS
multi-ancestry
phospholipids in very large HDL measurement
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.04
p 4.0e-24
N 136,016
Large GWAS
multi-ancestry
free cholesterol in large HDL measurement
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.04
p 3.0e-21
N 136,016
Large GWAS
multi-ancestry
total cholesterol change measurement, high density lipoprotein cholesterol measurement
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.04
p 8.0e-21
N 136,016
Large GWAS
multi-ancestry
HDL particle size
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.04
p 1.0e-19
N 136,016
Large GWAS
multi-ancestry
triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.04
p 4.0e-18
N 136,016
Large GWAS
multi-ancestry
serum albumin amount
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.02
p 4.0e-14
N 542,276
Major Consortium StudyLarge GWAS
multi-ancestry
erythrocyte volume
Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele C
OR 0.02
p 5.0e-14
N 408,112
Large GWAS
European
cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele T
OR 0.03
p 2.0e-13
N 136,016
Large GWAS
multi-ancestry
▶Research that mentions this SNP (1)
▶The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohortsAssociationN=33,282Juha Karvanen et al.(2009)· Genetic Epidemiology
The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts
AssociationN=33,282Juha Karvanen et al.(2009)· Genetic Epidemiology
Prospective cohort study of 33,282 individuals from the MORGAM Project investigating SNPs from recent GWAS in relation to incident coronary heart disease (CHD), stroke, and total mortality. SNP rs1333049 (9p21.3) was associated with both CHD (HR=1.20, 95% CI 1.08-1.34) and stroke, rs11670734 (19q12) with total mortality and stroke, and several SNPs associated with lipid levels and blood pressure.
Traits studied:Blood pressureCoronary heart diseaseHDL cholesterolMyocardial infarctionNon-HDL cholesterolStrokeTotal mortality
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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