rs297346

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Thorp JG et al. “Symptom-level modelling unravels the shared genetic architecture of anxiety and depression.” Nature Human Behaviour 5(10):1432-1442 (2021)
Allele A
OR 0.02
p 8.0e-14
N 136,610
Large GWAS
European

neuroticism measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 6.53
p 7.0e-11
N 380,506
Large GWAS
European
Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele A
OR 0.01
p 1.0e-9
N 523,783
Large GWAS
European
Luciano M et al. “Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.” Nature Genetics 50(1):6-11 (2018)
Allele A
OR 5.64
p 2.0e-8
N 329,821
Large GWAS
European
Hill WD et al. “Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life.” Molecular Psychiatry 25(11):3034-3052 (2020)
Allele A
OR 0.01
p 2.0e-8
N 270,059
Large GWAS
European

mood instability measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 6.23
p 5.0e-10
N 373,733
Large GWAS
European

depressive symptom measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele G
OR 0.01
p 2.0e-9
N 1,067,913
Large GWAS
European

wellbeing measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele G
OR 0.01
p 2.0e-9
N 410,603
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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