rs35233100

This variant is located in the MADD gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glucose measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.04
p 1.0e-15
N 325,386
Major Consortium StudyLarge GWAS
multi-ancestry

insulin measurement

Huyghe JR et al. “Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.” Nature Genetics 45(2):197-201 (2013)
Allele T
OR 0.10
p 8.0e-15
N 8,229
Large GWAS
European

HbA1c measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.04
p 1.0e-14
N 338,919
Major Consortium StudyLarge GWAS
multi-ancestry
Willems SM et al. “Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.” Wellcome Open Research 8:483 (2023)
Allele T
OR 0.01
p 1.0e-8
N 144,060
Large GWAS
multi-ancestry

chronotype measurement

Jones SE et al. “Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.” Nature Communications 10(1):343 (2019)
Allele T
OR 0.02
p 4.0e-12
N 449,734
Large GWAS
European
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ClinVar annotation

Benign
2 submitters

MADD-related disorder; Hepatocellular carcinoma; Adrenocortical carcinoma, hereditary; Uveal melanoma; Malignant lymphoma, large B-cell, diffuse; Colon adenocarcinoma; Colorectal cancer; Uterine corpus endometrial carcinoma; Lymphoma; Cholangiocarcinoma; Thymoma; Acute myeloid leukemia

View on ClinVar →

About MADD

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

View all MADD variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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