rs35923643
This is a regulatory region variant variant in the GRAMD1B gene.
▶GWAS Catalog Trait Associations (12)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (12)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
chronic lymphocytic leukemia
Law PJ et al. “Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.” Nature Communications 8:14175 (2017)
Allele G
OR 1.63
p 4.0e-58
N 17,691
Large GWAS
European
Berndt SI et al. “Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.” Nature Communications 7:10933 (2016)
Allele G
OR 1.66
p 2.0e-40
N 10,767
Meta-analysisLarge GWAS
multi-ancestry
CD5 antigen-like measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.08
p 6.0e-35
N 47,745
Large GWAS
European
annexin A1 measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.08
p 6.0e-27
N 47,745
Large GWAS
European
level of protein ZNRD2 in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.07
p 4.0e-25
N 47,745
Large GWAS
European
blood protein amount
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 1.0e-17
N 47,745
Large GWAS
European
level of trifunctional purine biosynthetic protein adenosine-3 in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.07
p 8.0e-17
N 47,745
Large GWAS
European
fas apoptotic inhibitory molecule 3 measurement
Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.13
p 2.0e-15
N 10,708
Large GWAS
European
lymphocyte percentage of leukocytes
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.02
p 1.0e-14
N 394,642
Large GWAS
European
Hodgkins lymphoma, multiple myeloma, non-Hodgkins lymphoma
Berndt SI et al. “Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.” Leukemia 36(12):2835-2844 (2022)
Allele G
OR 1.19
p 8.0e-13
N 32,625
Large GWAS
European
serum IgM amount
Chen X et al. “A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia.” Human Molecular Genetics 27(10):1809-1818 (2018)
Allele G
OR 0.19
p 4.0e-11
N 3,002
Large GWAS
European
About GRAMD1B
Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all GRAMD1B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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